Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4
Identifieur interne : 000424 ( Main/Exploration ); précédent : 000423; suivant : 000425Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4
Auteurs : Lisa D. Volk-Draper [États-Unis] ; Kelly L. Hall [États-Unis] ; Andrew C. Wilber [États-Unis] ; Sophia Ran [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2017.
Abstract
Myeloid-derived lymphatic endothelial cells (M-LECP) are induced by inflammation and play an important role in adult lymphangiogenesis. However, the mechanisms driving M-LECP differentiation are currently unclear. We previously showed that activation of Toll-like receptor-4 (TLR4) induces myeloid-lymphatic transition (MLT) of immortalized mouse myeloid cells. Here the goals were to assess the potential of different TLR4 ligands to induce pro-lymphatic reprogramming in human and mouse primary myeloid cells and to identify transcriptional changes regulating this process.
Human and mouse myeloid cells were reprogrammed to the lymphatic phenotype by TLR4 ligands including lipopolysaccharide (LPS), recombinant high mobility group box 1 protein (HMGB1), and paclitaxel. TLR4 induced similar MLT in cells from mice of different strains and immune status. Commonly induced genes were detected by transcriptional profiling in human and mouse myeloid cells from either immunocompetent or immunodeficient mice. Shared trends included: (1) novel expression of lymphatic-specific markers vascular endothelial growth factor receptor-3 (VEGFR-3), lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) and podoplanin (PDPN) largely absent prior to induction; (2) lack of notable changes in blood vessel-specific markers; (3) transient expression of VEGFR-3, but sustained increase of vascular endothelial growth factor-C (VEGF-C) and a variety of inflammatory cytokines; (4) dependency of VEGFR-3 upregulation and other LEC genes on NF-κB; and (5) novel expression of lymphatic-specific (e.g., PROX1) and stem/progenitor (e.g., E2F1) transcription factors known for their roles in adult and embryonic vascular formation. M-LECP generated by TLR4 ligands
We established a novel TLR4-dependent protocol for
Url:
DOI: 10.1371/journal.pone.0179257
PubMed: 28598999
PubMed Central: 5466303
Affiliations:
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Hall</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL</wicri:regionArea><wicri:noRegion>IL</wicri:noRegion></affiliation></author><author><name sortKey="Wilber, Andrew C" sort="Wilber, Andrew C" uniqKey="Wilber A" first="Andrew C." last="Wilber">Andrew C. 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Volk-Draper</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL</wicri:regionArea><wicri:noRegion>IL</wicri:noRegion></affiliation></author><author><name sortKey="Hall, Kelly L" sort="Hall, Kelly L" uniqKey="Hall K" first="Kelly L." last="Hall">Kelly L. Hall</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL</wicri:regionArea><wicri:noRegion>IL</wicri:noRegion></affiliation></author><author><name sortKey="Wilber, Andrew C" sort="Wilber, Andrew C" uniqKey="Wilber A" first="Andrew C." last="Wilber">Andrew C. Wilber</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL</wicri:regionArea><wicri:noRegion>IL</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Simmons Cancer Institute, Southern Illinois University School of Medicine, Springfield, IL, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Simmons Cancer Institute, Southern Illinois University School of Medicine, Springfield, IL</wicri:regionArea><wicri:noRegion>IL</wicri:noRegion></affiliation></author><author><name sortKey="Ran, Sophia" sort="Ran, Sophia" uniqKey="Ran S" first="Sophia" last="Ran">Sophia Ran</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL</wicri:regionArea><wicri:noRegion>IL</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Simmons Cancer Institute, Southern Illinois University School of Medicine, Springfield, IL, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Simmons Cancer Institute, Southern Illinois University School of Medicine, Springfield, IL</wicri:regionArea><wicri:noRegion>IL</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>Myeloid-derived lymphatic endothelial cells (M-LECP) are induced by inflammation and play an important role in adult lymphangiogenesis. However, the mechanisms driving M-LECP differentiation are currently unclear. We previously showed that activation of Toll-like receptor-4 (TLR4) induces myeloid-lymphatic transition (MLT) of immortalized mouse myeloid cells. Here the goals were to assess the potential of different TLR4 ligands to induce pro-lymphatic reprogramming in human and mouse primary myeloid cells and to identify transcriptional changes regulating this process.</p></sec><sec id="sec002"><title>Methodology/Principal findings</title><p>Human and mouse myeloid cells were reprogrammed to the lymphatic phenotype by TLR4 ligands including lipopolysaccharide (LPS), recombinant high mobility group box 1 protein (HMGB1), and paclitaxel. TLR4 induced similar MLT in cells from mice of different strains and immune status. Commonly induced genes were detected by transcriptional profiling in human and mouse myeloid cells from either immunocompetent or immunodeficient mice. Shared trends included: (1) novel expression of lymphatic-specific markers vascular endothelial growth factor receptor-3 (VEGFR-3), lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) and podoplanin (PDPN) largely absent prior to induction; (2) lack of notable changes in blood vessel-specific markers; (3) transient expression of VEGFR-3, but sustained increase of vascular endothelial growth factor-C (VEGF-C) and a variety of inflammatory cytokines; (4) dependency of VEGFR-3 upregulation and other LEC genes on NF-κB; and (5) novel expression of lymphatic-specific (e.g., PROX1) and stem/progenitor (e.g., E2F1) transcription factors known for their roles in adult and embryonic vascular formation. M-LECP generated by TLR4 ligands <italic>in vitro</italic> were functional <italic>in vivo</italic> as demonstrated by significantly increased lymphatic vessel density and lymphatic metastasis detected in orthotopic breast cancer models.</p></sec><sec id="sec003"><title>Conclusions/Significance</title><p>We established a novel TLR4-dependent protocol for <italic>in vitro</italic> production of functionally competent M-LECP from primary human or mouse myeloid cells and identified many potential regulators of this process. This information can be further exploited for research and therapeutic purposes.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kesler, Ct" uniqKey="Kesler C">CT Kesler</name></author><author><name sortKey="Liao, S" uniqKey="Liao S">S Liao</name></author><author><name sortKey="Munn, Ll" uniqKey="Munn L">LL Munn</name></author><author><name sortKey="Padera, Tp" uniqKey="Padera T">TP Padera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ran, S" uniqKey="Ran S">S Ran</name></author><author><name sortKey="Volk, L" uniqKey="Volk L">L Volk</name></author><author><name sortKey="Hall, K" uniqKey="Hall K">K Hall</name></author><author><name sortKey="Flister, Mj" uniqKey="Flister M">MJ Flister</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sleeman, Jp" uniqKey="Sleeman J">JP Sleeman</name></author><author><name sortKey="Thiele, W" uniqKey="Thiele W">W Thiele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alunno, A" uniqKey="Alunno A">A Alunno</name></author><author><name sortKey="Ibba Manneschi, L" uniqKey="Ibba Manneschi L">L Ibba-Manneschi</name></author><author><name sortKey="Bistoni, O" uniqKey="Bistoni O">O Bistoni</name></author><author><name sortKey="Rosa, I" uniqKey="Rosa I">I Rosa</name></author><author><name sortKey="Caterbi, S" uniqKey="Caterbi S">S Caterbi</name></author><author><name sortKey="Gerli, R" uniqKey="Gerli R">R Gerli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Rajantie, I" uniqKey="Rajantie I">I Rajantie</name></author><author><name sortKey="Ilmonen, M" uniqKey="Ilmonen M">M Ilmonen</name></author><author><name sortKey="Makinen, T" uniqKey="Makinen T">T Makinen</name></author><author><name sortKey="Karkkainen, Mj" uniqKey="Karkkainen M">MJ Karkkainen</name></author><author><name sortKey="Haiko, P" uniqKey="Haiko P">P Haiko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gordon, Ej" uniqKey="Gordon E">EJ Gordon</name></author><author><name sortKey="Rao, S" uniqKey="Rao S">S Rao</name></author><author><name sortKey="Pollard, Jw" uniqKey="Pollard J">JW Pollard</name></author><author><name sortKey="Nutt, Sl" uniqKey="Nutt S">SL Nutt</name></author><author><name sortKey="Lang, Ra" uniqKey="Lang R">RA Lang</name></author><author><name sortKey="Harvey, Nl" uniqKey="Harvey N">NL Harvey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Egeblad, M" uniqKey="Egeblad M">M Egeblad</name></author><author><name sortKey="Karkkainen, Mj" uniqKey="Karkkainen M">MJ Karkkainen</name></author><author><name sortKey="Kubo, H" uniqKey="Kubo H">H Kubo</name></author><author><name sortKey="Yla Herttuala, S" uniqKey="Yla Herttuala S">S Yla-Herttuala</name></author><author><name sortKey="Jaattela, M" uniqKey="Jaattela M">M Jaattela</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Achen, Mg" uniqKey="Achen M">MG Achen</name></author><author><name sortKey="Williams, Ra" uniqKey="Williams R">RA Williams</name></author><author><name sortKey="Baldwin, Me" uniqKey="Baldwin M">ME Baldwin</name></author><author><name sortKey="Lai, P" uniqKey="Lai P">P Lai</name></author><author><name sortKey="Roufail, S" uniqKey="Roufail S">S Roufail</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ji, Rc" uniqKey="Ji R">RC Ji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding, M" uniqKey="Ding M">M Ding</name></author><author><name sortKey="Fu, X" uniqKey="Fu X">X Fu</name></author><author><name sortKey="Tan, H" uniqKey="Tan H">H Tan</name></author><author><name sortKey="Wang, R" uniqKey="Wang R">R Wang</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name></author><author><name sortKey="Ding, S" uniqKey="Ding S">S Ding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zumsteg, A" uniqKey="Zumsteg A">A Zumsteg</name></author><author><name sortKey="Baeriswyl, V" uniqKey="Baeriswyl V">V Baeriswyl</name></author><author><name sortKey="Imaizumi, N" uniqKey="Imaizumi N">N Imaizumi</name></author><author><name sortKey="Schwendener, R" uniqKey="Schwendener R">R Schwendener</name></author><author><name sortKey="Ruegg, C" uniqKey="Ruegg C">C Ruegg</name></author><author><name sortKey="Christofori, G" uniqKey="Christofori G">G Christofori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Jy" uniqKey="Lee J">JY Lee</name></author><author><name sortKey="Park, C" uniqKey="Park C">C Park</name></author><author><name sortKey="Cho, Yp" uniqKey="Cho Y">YP Cho</name></author><author><name sortKey="Lee, E" uniqKey="Lee E">E Lee</name></author><author><name sortKey="Kim, H" uniqKey="Kim H">H Kim</name></author><author><name sortKey="Kim, P" uniqKey="Kim P">P Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kerjaschki, D" uniqKey="Kerjaschki D">D Kerjaschki</name></author><author><name sortKey="Huttary, N" uniqKey="Huttary N">N Huttary</name></author><author><name sortKey="Raab, I" uniqKey="Raab I">I Raab</name></author><author><name sortKey="Regele, H" uniqKey="Regele H">H Regele</name></author><author><name sortKey="Bojarski Nagy, K" uniqKey="Bojarski Nagy K">K Bojarski-Nagy</name></author><author><name sortKey="Bartel, G" uniqKey="Bartel G">G Bartel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Religa, P" uniqKey="Religa P">P Religa</name></author><author><name sortKey="Cao, R" uniqKey="Cao R">R Cao</name></author><author><name sortKey="Bjorndahl, M" uniqKey="Bjorndahl M">M Bjorndahl</name></author><author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z Zhou</name></author><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z Zhu</name></author><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maruyama, K" uniqKey="Maruyama K">K Maruyama</name></author><author><name sortKey="Ii, M" uniqKey="Ii M">M Ii</name></author><author><name sortKey="Cursiefen, C" uniqKey="Cursiefen C">C Cursiefen</name></author><author><name sortKey="Jackson, Dg" uniqKey="Jackson D">DG Jackson</name></author><author><name sortKey="Keino, H" uniqKey="Keino H">H Keino</name></author><author><name sortKey="Tomita, M" uniqKey="Tomita M">M Tomita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ran, S" uniqKey="Ran S">S Ran</name></author><author><name sortKey="Montgomery, Ke" uniqKey="Montgomery K">KE Montgomery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kerjaschki, D" uniqKey="Kerjaschki D">D Kerjaschki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nolan, Dj" uniqKey="Nolan D">DJ Nolan</name></author><author><name sortKey="Ciarrocchi, A" uniqKey="Ciarrocchi A">A Ciarrocchi</name></author><author><name sortKey="Mellick, As" uniqKey="Mellick A">AS Mellick</name></author><author><name sortKey="Jaggi, Js" uniqKey="Jaggi J">JS Jaggi</name></author><author><name sortKey="Bambino, K" uniqKey="Bambino K">K Bambino</name></author><author><name sortKey="Gupta, S" uniqKey="Gupta S">S Gupta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nguyen, Va" uniqKey="Nguyen V">VA Nguyen</name></author><author><name sortKey="Furhapter, C" uniqKey="Furhapter C">C Furhapter</name></author><author><name sortKey="Obexer, P" uniqKey="Obexer P">P Obexer</name></author><author><name sortKey="Stossel, H" uniqKey="Stossel H">H Stossel</name></author><author><name sortKey="Romani, N" uniqKey="Romani N">N Romani</name></author><author><name sortKey="Sepp, N" uniqKey="Sepp N">N Sepp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiu, H" uniqKey="Qiu H">H Qiu</name></author><author><name sortKey="Cao, L" uniqKey="Cao L">L Cao</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Xu, H" uniqKey="Xu H">H Xu</name></author><author><name sortKey="Liang, Z" uniqKey="Liang Z">Z Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, Kl" uniqKey="Hall K">KL Hall</name></author><author><name sortKey="Volk Draper, Ld" uniqKey="Volk Draper L">LD Volk-Draper</name></author><author><name sortKey="Flister, Mj" uniqKey="Flister M">MJ Flister</name></author><author><name sortKey="Ran, S" uniqKey="Ran S">S Ran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bogos, K" uniqKey="Bogos K">K Bogos</name></author><author><name sortKey="Renyi Vamos, F" uniqKey="Renyi Vamos F">F Renyi-Vamos</name></author><author><name sortKey="Dobos, J" uniqKey="Dobos J">J Dobos</name></author><author><name sortKey="Kenessey, I" uniqKey="Kenessey I">I Kenessey</name></author><author><name sortKey="Tovari, J" uniqKey="Tovari J">J Tovari</name></author><author><name sortKey="Timar, J" uniqKey="Timar J">J Timar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van T Hull, Ef" uniqKey="Van T Hull E">EF Van't Hull</name></author><author><name sortKey="Bron, S" uniqKey="Bron S">S Bron</name></author><author><name sortKey="Henry, L" uniqKey="Henry L">L Henry</name></author><author><name sortKey="Ifticene Treboux, A" uniqKey="Ifticene Treboux A">A Ifticene-Treboux</name></author><author><name sortKey="Turrini, R" uniqKey="Turrini R">R Turrini</name></author><author><name sortKey="Coukos, G" uniqKey="Coukos G">G Coukos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Sj" uniqKey="Lee S">SJ Lee</name></author><author><name sortKey="Park, C" uniqKey="Park C">C Park</name></author><author><name sortKey="Lee, Jy" uniqKey="Lee J">JY Lee</name></author><author><name sortKey="Kim, S" uniqKey="Kim S">S Kim</name></author><author><name sortKey="Kwon, Pj" uniqKey="Kwon P">PJ Kwon</name></author><author><name sortKey="Kim, W" uniqKey="Kim W">W Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zumsteg, A" uniqKey="Zumsteg A">A Zumsteg</name></author><author><name sortKey="Christofori, G" uniqKey="Christofori G">G Christofori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salven, P" uniqKey="Salven P">P Salven</name></author><author><name sortKey="Mustjoki, S" uniqKey="Mustjoki S">S Mustjoki</name></author><author><name sortKey="Alitalo, R" uniqKey="Alitalo R">R Alitalo</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author><author><name sortKey="Rafii, S" uniqKey="Rafii S">S Rafii</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, H" uniqKey="Suzuki H">H Suzuki</name></author><author><name sortKey="Watabe, T" uniqKey="Watabe T">T Watabe</name></author><author><name sortKey="Kato, M" uniqKey="Kato M">M Kato</name></author><author><name sortKey="Miyazawa, K" uniqKey="Miyazawa K">K Miyazawa</name></author><author><name sortKey="Miyazono, K" uniqKey="Miyazono K">K Miyazono</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tawada, M" uniqKey="Tawada M">M Tawada</name></author><author><name sortKey="Hayashi, S" uniqKey="Hayashi S">S Hayashi</name></author><author><name sortKey="Ikegame, Y" uniqKey="Ikegame Y">Y Ikegame</name></author><author><name sortKey="Nakashima, S" uniqKey="Nakashima S">S Nakashima</name></author><author><name sortKey="Yoshida, K" uniqKey="Yoshida K">K Yoshida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Conrad, C" uniqKey="Conrad C">C Conrad</name></author><author><name sortKey="Niess, H" uniqKey="Niess H">H Niess</name></author><author><name sortKey="Huss, R" uniqKey="Huss R">R Huss</name></author><author><name sortKey="Huber, S" uniqKey="Huber S">S Huber</name></author><author><name sortKey="Von L, I" uniqKey="Von L I">I von L</name></author><author><name sortKey="Nelson, Pj" uniqKey="Nelson P">PJ Nelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Chen, Xh" uniqKey="Chen X">XH Chen</name></author><author><name sortKey="Li, Fg" uniqKey="Li F">FG Li</name></author><author><name sortKey="Chen, Yx" uniqKey="Chen Y">YX Chen</name></author><author><name sortKey="Gu, Lq" uniqKey="Gu L">LQ Gu</name></author><author><name sortKey="Zhu, Jk" uniqKey="Zhu J">JK Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hur, J" uniqKey="Hur J">J Hur</name></author><author><name sortKey="Jang, Jh" uniqKey="Jang J">JH Jang</name></author><author><name sortKey="Oh, Iy" uniqKey="Oh I">IY Oh</name></author><author><name sortKey="Choi, Ji" uniqKey="Choi J">JI Choi</name></author><author><name sortKey="Yun, Jy" uniqKey="Yun J">JY Yun</name></author><author><name sortKey="Kim, J" uniqKey="Kim J">J Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Changming, W" uniqKey="Changming W">W Changming</name></author><author><name sortKey="Xin, L" uniqKey="Xin L">L Xin</name></author><author><name sortKey="Hua, T" uniqKey="Hua T">T Hua</name></author><author><name sortKey="Shikun, W" uniqKey="Shikun W">W Shikun</name></author><author><name sortKey="Qiong, X" uniqKey="Qiong X">X Qiong</name></author><author><name sortKey="Zhigeng, Z" uniqKey="Zhigeng Z">Z Zhigeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, S" uniqKey="Kang S">S Kang</name></author><author><name sortKey="Lee, Sp" uniqKey="Lee S">SP Lee</name></author><author><name sortKey="Kim, Ke" uniqKey="Kim K">KE Kim</name></author><author><name sortKey="Kim, Hz" uniqKey="Kim H">HZ Kim</name></author><author><name sortKey="Memet, S" uniqKey="Memet S">S Memet</name></author><author><name sortKey="Koh, Gy" uniqKey="Koh G">GY Koh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zampell, J" uniqKey="Zampell J">J Zampell</name></author><author><name sortKey="Elhadad, S" uniqKey="Elhadad S">S Elhadad</name></author><author><name sortKey="Avraham, T" uniqKey="Avraham T">T Avraham</name></author><author><name sortKey="Weitman, E" uniqKey="Weitman E">E Weitman</name></author><author><name sortKey="Aschen, S" uniqKey="Aschen S">S Aschen</name></author><author><name sortKey="Yan, A" uniqKey="Yan A">A Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name></author><author><name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volk, Ld" uniqKey="Volk L">LD Volk</name></author><author><name sortKey="Flister, Mj" uniqKey="Flister M">MJ Flister</name></author><author><name sortKey="Chihade, D" uniqKey="Chihade D">D Chihade</name></author><author><name sortKey="Desai, N" uniqKey="Desai N">N Desai</name></author><author><name sortKey="Trieu, V" uniqKey="Trieu V">V Trieu</name></author><author><name sortKey="Ran, S" uniqKey="Ran S">S Ran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volk Draper, L" uniqKey="Volk Draper L">L Volk-Draper</name></author><author><name sortKey="Hall, K" uniqKey="Hall K">K Hall</name></author><author><name sortKey="Griggs, C" uniqKey="Griggs C">C Griggs</name></author><author><name sortKey="Rajput, S" uniqKey="Rajput S">S Rajput</name></author><author><name sortKey="Kohio, P" uniqKey="Kohio P">P Kohio</name></author><author><name sortKey="Denardo, D" uniqKey="Denardo D">D DeNardo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poltorak, A" uniqKey="Poltorak A">A Poltorak</name></author><author><name sortKey="He, X" uniqKey="He X">X He</name></author><author><name sortKey="Smirnova, I" uniqKey="Smirnova I">I Smirnova</name></author><author><name sortKey="Liu, My" uniqKey="Liu M">MY Liu</name></author><author><name sortKey="Van, Hc" uniqKey="Van H">HC Van</name></author><author><name sortKey="Du, X" uniqKey="Du X">X Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, L" uniqKey="Han L">L Han</name></author><author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Jia, J" uniqKey="Jia J">J Jia</name></author><author><name sortKey="Zhao, M" uniqKey="Zhao M">M Zhao</name></author><author><name sortKey="Fan, Y" uniqKey="Fan Y">Y Fan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ran, S" uniqKey="Ran S">S Ran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kriehuber, E" uniqKey="Kriehuber E">E Kriehuber</name></author><author><name sortKey="Breiteneder Geleff, S" uniqKey="Breiteneder Geleff S">S Breiteneder-Geleff</name></author><author><name sortKey="Groeger, M" uniqKey="Groeger M">M Groeger</name></author><author><name sortKey="Soleiman, A" uniqKey="Soleiman A">A Soleiman</name></author><author><name sortKey="Schoppmann, Sf" uniqKey="Schoppmann S">SF Schoppmann</name></author><author><name sortKey="Stingl, G" uniqKey="Stingl G">G Stingl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alphonse, Rs" uniqKey="Alphonse R">RS Alphonse</name></author><author><name sortKey="Vadivel, A" uniqKey="Vadivel A">A Vadivel</name></author><author><name sortKey="Zhong, S" uniqKey="Zhong S">S Zhong</name></author><author><name sortKey="Mcconaghy, S" uniqKey="Mcconaghy S">S McConaghy</name></author><author><name sortKey="Ohls, R" uniqKey="Ohls R">R Ohls</name></author><author><name sortKey="Yoder, Mc" uniqKey="Yoder M">MC Yoder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robertson, Rt" uniqKey="Robertson R">RT Robertson</name></author><author><name sortKey="Levine, St" uniqKey="Levine S">ST Levine</name></author><author><name sortKey="Haynes, Sm" uniqKey="Haynes S">SM Haynes</name></author><author><name sortKey="Gutierrez, P" uniqKey="Gutierrez P">P Gutierrez</name></author><author><name sortKey="Baratta, Jl" uniqKey="Baratta J">JL Baratta</name></author><author><name sortKey="Tan, Z" uniqKey="Tan Z">Z Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finnin, M" uniqKey="Finnin M">M Finnin</name></author><author><name sortKey="Hamilton, Ja" uniqKey="Hamilton J">JA Hamilton</name></author><author><name sortKey="Moss, St" uniqKey="Moss S">ST Moss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Byrd Leifer, Ca" uniqKey="Byrd Leifer C">CA Byrd-Leifer</name></author><author><name sortKey="Block, Ef" uniqKey="Block E">EF Block</name></author><author><name sortKey="Takeda, K" uniqKey="Takeda K">K Takeda</name></author><author><name sortKey="Akira, S" uniqKey="Akira S">S Akira</name></author><author><name sortKey="Ding, A" uniqKey="Ding A">A Ding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Denardo, Dg" uniqKey="Denardo D">DG DeNardo</name></author><author><name sortKey="Brennan, Dj" uniqKey="Brennan D">DJ Brennan</name></author><author><name sortKey="Rexhepaj, E" uniqKey="Rexhepaj E">E Rexhepaj</name></author><author><name sortKey="Ruffell, B" uniqKey="Ruffell B">B Ruffell</name></author><author><name sortKey="Shiao, Sl" uniqKey="Shiao S">SL Shiao</name></author><author><name sortKey="Madden, Sf" uniqKey="Madden S">SF Madden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flister, Mj" uniqKey="Flister M">MJ Flister</name></author><author><name sortKey="Wilber, A" uniqKey="Wilber A">A Wilber</name></author><author><name sortKey="Hall, Kl" uniqKey="Hall K">KL Hall</name></author><author><name sortKey="Iwata, C" uniqKey="Iwata C">C Iwata</name></author><author><name sortKey="Miyazono, K" uniqKey="Miyazono K">K Miyazono</name></author><author><name sortKey="Nisato, Re" uniqKey="Nisato R">RE Nisato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andreakos, E" uniqKey="Andreakos E">E Andreakos</name></author><author><name sortKey="Sacre, Sm" uniqKey="Sacre S">SM Sacre</name></author><author><name sortKey="Smith, C" uniqKey="Smith C">C Smith</name></author><author><name sortKey="Lundberg, A" uniqKey="Lundberg A">A Lundberg</name></author><author><name sortKey="Kiriakidis, S" uniqKey="Kiriakidis S">S Kiriakidis</name></author><author><name sortKey="Stonehouse, T" uniqKey="Stonehouse T">T Stonehouse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bork, Pm" uniqKey="Bork P">PM Bork</name></author><author><name sortKey="Schmitz, Ml" uniqKey="Schmitz M">ML Schmitz</name></author><author><name sortKey="Kuhnt, M" uniqKey="Kuhnt M">M Kuhnt</name></author><author><name sortKey="Escher, C" uniqKey="Escher C">C Escher</name></author><author><name sortKey="Heinrich, M" uniqKey="Heinrich M">M Heinrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munoz, C" uniqKey="Munoz C">C Munoz</name></author><author><name sortKey="Pascual Salcedo, D" uniqKey="Pascual Salcedo D">D Pascual-Salcedo</name></author><author><name sortKey="Castellanos, Mc" uniqKey="Castellanos M">MC Castellanos</name></author><author><name sortKey="Alfranca, A" uniqKey="Alfranca A">A Alfranca</name></author><author><name sortKey="Aragones, J" uniqKey="Aragones J">J Aragones</name></author><author><name sortKey="Vara, A" uniqKey="Vara A">A Vara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jang, Bc" uniqKey="Jang B">BC Jang</name></author><author><name sortKey="Sung, Sh" uniqKey="Sung S">SH Sung</name></author><author><name sortKey="Park, Jg" uniqKey="Park J">JG Park</name></author><author><name sortKey="Park, Jw" uniqKey="Park J">JW Park</name></author><author><name sortKey="Suh, Mh" uniqKey="Suh M">MH Suh</name></author><author><name sortKey="Choi, Ih" uniqKey="Choi I">IH Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tawada, M" uniqKey="Tawada M">M Tawada</name></author><author><name sortKey="Hayashi, S" uniqKey="Hayashi S">S Hayashi</name></author><author><name sortKey="Osada, S" uniqKey="Osada S">S Osada</name></author><author><name sortKey="Nakashima, S" uniqKey="Nakashima S">S Nakashima</name></author><author><name sortKey="Yoshida, K" uniqKey="Yoshida K">K Yoshida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, Yz" uniqKey="Tan Y">YZ Tan</name></author><author><name sortKey="Wang, Hj" uniqKey="Wang H">HJ Wang</name></author><author><name sortKey="Zhang, Mh" uniqKey="Zhang M">MH Zhang</name></author><author><name sortKey="Quan, Z" uniqKey="Quan Z">Z Quan</name></author><author><name sortKey="Li, T" uniqKey="Li T">T Li</name></author><author><name sortKey="He, Qz" uniqKey="He Q">QZ He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="He, J" uniqKey="He J">J He</name></author><author><name sortKey="Zhong, D" uniqKey="Zhong D">D Zhong</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Liang, H" uniqKey="Liang H">H Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Covert, Mw" uniqKey="Covert M">MW Covert</name></author><author><name sortKey="Leung, Th" uniqKey="Leung T">TH Leung</name></author><author><name sortKey="Gaston, Je" uniqKey="Gaston J">JE Gaston</name></author><author><name sortKey="Baltimore, D" uniqKey="Baltimore D">D Baltimore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cao, R" uniqKey="Cao R">R Cao</name></author><author><name sortKey="Bjorndahl, Ma" uniqKey="Bjorndahl M">MA Bjorndahl</name></author><author><name sortKey="Religa, P" uniqKey="Religa P">P Religa</name></author><author><name sortKey="Clasper, S" uniqKey="Clasper S">S Clasper</name></author><author><name sortKey="Garvin, S" uniqKey="Garvin S">S Garvin</name></author><author><name sortKey="Galter, D" uniqKey="Galter D">D Galter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stec, M" uniqKey="Stec M">M Stec</name></author><author><name sortKey="Baran, J" uniqKey="Baran J">J Baran</name></author><author><name sortKey="Baj Krzyworzeka, M" uniqKey="Baj Krzyworzeka M">M Baj-Krzyworzeka</name></author><author><name sortKey="Weglarczyk, K" uniqKey="Weglarczyk K">K Weglarczyk</name></author><author><name sortKey="Gozdzik, J" uniqKey="Gozdzik J">J Gozdzik</name></author><author><name sortKey="Siedlar, M" uniqKey="Siedlar M">M Siedlar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Bailey, As" uniqKey="Bailey A">AS Bailey</name></author><author><name sortKey="Goldman, Dc" uniqKey="Goldman D">DC Goldman</name></author><author><name sortKey="Swain, Jr" uniqKey="Swain J">JR Swain</name></author><author><name sortKey="Wong, Mh" uniqKey="Wong M">MH Wong</name></author><author><name sortKey="Streeter, Pr" uniqKey="Streeter P">PR Streeter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kerjaschki, D" uniqKey="Kerjaschki D">D Kerjaschki</name></author><author><name sortKey="Regele, Hm" uniqKey="Regele H">HM Regele</name></author><author><name sortKey="Moosberger, I" uniqKey="Moosberger I">I Moosberger</name></author><author><name sortKey="Nagy Bojarski, K" uniqKey="Nagy Bojarski K">K Nagy-Bojarski</name></author><author><name sortKey="Watschinger, B" uniqKey="Watschinger B">B Watschinger</name></author><author><name sortKey="Soleiman, A" uniqKey="Soleiman A">A Soleiman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Volk Draper, Lisa D" sort="Volk Draper, Lisa D" uniqKey="Volk Draper L" first="Lisa D." last="Volk-Draper">Lisa D. Volk-Draper</name></noRegion><name sortKey="Hall, Kelly L" sort="Hall, Kelly L" uniqKey="Hall K" first="Kelly L." last="Hall">Kelly L. Hall</name><name sortKey="Ran, Sophia" sort="Ran, Sophia" uniqKey="Ran S" first="Sophia" last="Ran">Sophia Ran</name><name sortKey="Ran, Sophia" sort="Ran, Sophia" uniqKey="Ran S" first="Sophia" last="Ran">Sophia Ran</name><name sortKey="Wilber, Andrew C" sort="Wilber, Andrew C" uniqKey="Wilber A" first="Andrew C." last="Wilber">Andrew C. Wilber</name><name sortKey="Wilber, Andrew C" sort="Wilber, Andrew C" uniqKey="Wilber A" first="Andrew C." last="Wilber">Andrew C. Wilber</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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